Cell BiologybioRxivPreprint
DNA Damage Driven Viability Loss and Transcriptional Reprogramming in Chinese Hamster Ovary Cell Perfusion Culture
Noah Hitchcock, Maxine Annoh, Luigi Grassi…·Christopher P. Toseland
The paper identifies DNA damage accumulation as a key factor limiting viability in Chinese hamster ovary cells during perfusion culture, showing impaired DNA damage response and transcriptional dysfunction.
DOI 10.64898/2026.03.16.712126