Molecular patterns and mechanisms of tumorigenesis in HPV-associated and HPV-independent sinonasal squamous cell carcinoma
Fernando Tadeu Zamunér, Sreenivasulu Gunti, Gabriel J. Starrett, Farhoud Faraji, Tiffany Toni, Anirudh Saraswathula, Kenny Vu, Anuj Kumar Gupta, Yan Zhang, Daniel L. Faden, Michael E. Bryan, Theresa W. Guo, Nicholas R. Rowan, Murugappan Ramanathan, Andrew P. Lane, , Nyall R. London
This study identifies molecular differences between HPV-associated and HPV-independent SNSCC, showing HPV drives tumorigenesis and suggesting YAP/TAZ and PI3K inhibition as therapeutic targets.
Nature Communications · Jun 11, 2025Peer-reviewedCancer Biology