Author

Joshua David Schoenfeld

Memorial Sloan Kettering Cancer CenterORCID 0000-0002-3970-9784Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:metabolomics· 1

Frequent Co-Authors

Santosha Adipudi VardhanaiD· 2 shared A. Ari HakimiiD· 1 shared Agustin Cardenas· 1 shared Alice Wei· 1 shared Beatrice D. ZhangiD· 1 shared Benjamin D. GreenbaumiD· 1 shared Benoı̂t RousseauiD· 1 shared Cameron G. RobertsiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersImmunology

Santosha Adipudi VardhanaORCID

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2 papers

Recent·Most cited

Cysteine reactivity profiling links metabolic rewiring to the dysfunctional human T cell proteome.

Hiroyuki Kojima, Charlotte R. Wayne, Luis F. Somarribas Patterson, Henry Sanford, Tzu-Jou Chen, Ya-Hui Lin, Joshua David Schoenfeld, Lisa H.F. McGary, Yanting Chen, Korbinian Nepomuk Kropp, Beatrice D. Zhang, Jahan A. Rahman, Tiffany L. Zhang, Nathalie Ropek, Cameron G. Roberts, , Ekaterina V. Vinogradova

In chronically stimulated human T cells, suppressed oxidative metabolism and nucleotide loss accompany MAP2K4 activation. Inhibiting MAP2K4 (with the MKK4/7 inhibitor BSJ-04-122) restored tumor-cell killing in vitro.

bioRxiv · Oct 2, 2026 · PreprintImmunology✦ In-depth digest

Neoantigen-reactive CD8+ T cell engagement marks exceptional survivors of pancreatic cancer

Marc Hilmi, Joshua David Schoenfeld, Wilson McKerrow, Yuval Elhanati, Catherine A. O’Connor, Shigeaki Umeda, Nicolas Lecomte, Jerry P. Melchor, Agustin Cardenas, Maria Lao, Vincenzo Nasca, Elias-Ramzey R. Karnoub, Nuray Tezcan, Zeynep Cagla Tarcan, Joanne F. Chou, , Wungki Park

The paper identifies TIE CD8+ T cell clonotypes associated with prolonged survival in pancreatic cancer patients and links resistance to stromal and immune barriers.

bioRxiv · Sep 18, 2026 · PreprintCancer Biology