Georg A. Holländer

Spatial remodeling of the thymic stroma with age disrupts niches for T cell selection and tolerance

This study maps spatial changes in the aging mouse thymus, revealing stromal reorganization that disrupts T cell selection and tolerance.

A chromatin relay from AIRE to ETS transcription factors sustains peripheral antigen expression in the thymic mimetic cells to ensure central tolerance.

The paper identifies EHF and ELF3 as key ETS transcription factors that sustain AIRE-primed gene expression in post-AIRE mimetic thymic epithelial cells, ensuring central tolerance.

Ly6d expression delineates two putative postnatal thymus epithelial progenitor cells that are differentially affected by ageing

This study identifies two postnatal thymus epithelial progenitor cell subpopulations defined by Ly6d expression, showing differential impact of ageing on their maintenance.

ASCL1 primes medullary thymic epithelial cell programs required for central tolerance

The paper identifies ASCL1 as a key regulator of mTEC function and central tolerance by analyzing single-cell RNA sequencing data from thymoma patients and mouse models.

Thymic epithelial organoids mediate T cell development

This study establishes thymic epithelial organoids that mimic in vivo thymus function and support T cell development in vitro.

Development in context: interferon response networks regulate human fetal thymic epithelial cell differentiation

This study uses single-cell transcriptomics to identify gene regulatory networks and lineage trajectories in human fetal thymic epithelial cells, revealing interferon response pathways that distinguish thymic epithelium from other anterior foregut-derived organs.