Sally A. Moody

This study investigates the role of PA2G4, MCRS1, and SOBP as regulators of SIX1+EYA transcriptional activity in mouse mandibular arch neural crest cells, revealing distinct mechanisms of regulation.

The paper uses mass spectrometry to analyze the SMO tissue and finds increased energy metabolism and reactive oxygen species, suggesting a role in gastrulation.

The paper shows that zebrafish inpp5ka and inpp5kb, duplicated from whole genome duplication, have diverged in expression and function, with inpp5ka more closely related to human INPP5K and inpp5kb losing catalytic activity.

This paper generates a six1-null line in Xenopus tropicalis using CRISPR/Cas9 to study development and congenital disease.

The paper shows Sobp interacts with Six1 in the nucleus, represses its transcriptional activity, and is essential for craniofacial development in Xenopus.

The paper investigates how mutations in SIX1 affect otic gene expression in Xenopus embryos, finding differential impacts on target genes like prdm1 and spry1.