William A. Liguore

Hybrid transcriptome assembly and annotation of Japanese macaque prefrontal cortex

The paper presents a hybrid transcriptome assembly and annotation of Japanese macaque prefrontal cortex using short- and long-read RNA sequencing data.

Aging macaques bridge the translational gap in perivascular space biology

This study shows that aging rhesus macaques exhibit age-dependent perivascular space burden, mirroring human patterns, and validates MRI-detected structures as perivascular spaces.

Prodromal pathogenesis of CLN7 Batten Disease revealed by multimodal biomarkers in macaques

The paper characterizes early CLN7 disease in macaques using multimodal biomarkers, revealing region-specific brain changes and neurodegeneration markers.

Longitudinal Investigation of Structural and Resting-State Effective Connectivity Alterations in a Non-Human Primate Model of Huntington's Disease

This study examines longitudinal changes in structural and effective connectivity in a non-human primate HD model, finding reduced structural connectivity and early effective connectivity changes.

Selective Vulnerability of Layer 5a Corticostriatal Neurons in Huntington's Disease

The paper identifies layer 5a corticostriatal neurons as selectively vulnerable in Huntington's disease using single nucleus RNA sequencing and shows they have extensive mHTT-CAG expansions.

A novel rhesus macaque model of Huntington's disease recapitulates key neuropathological changes along with progressive motor and cognitive decline

The macaque brain ONPRC18 template with combined gray and white matter labelmap for multimodal neuroimaging studies of nonhuman primates

The paper creates a multimodal brain atlas for rhesus macaques combining structural and diffusion imaging data to enable consistent region identification across imaging modalities.

Intra-striatal AAV2.retro administration leads to extensive retrograde transport in the rhesus macaque brain: implications for disease modeling and therapeutic development

This study shows AAV2.retro efficiently transports gene cargo retrogradely in rhesus macaque brains, enabling widespread transduction of brain circuits relevant to Huntington's disease.