Author

Stef De Lombaerde

University of AntwerpORCID 0000-0002-5307-3575Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:imaging· 3 Organism:mouse· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

Alan MirandaiD· 3 shared Celia DomingueziD· 3 shared Daniele BertoglioiD· 3 shared Franziska ZajicekiD· 3 shared Jeroen A.J. VerhaegheiD· 3 shared Jonathan BardiD· 3 shared Longbin LiuiD· 3 shared Steven G. StaelensiD· 3 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersNeuroscience

Alan MirandaORCID

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Author profile →

3 papers

Recent·Most cited

Preclinical evaluation of CHDI-009R for quantification of mutant huntingtin aggregates

Franziska Zajicek, Liesbeth Everix, Annemie Van Eetveldt, Jeroen A.J. Verhaeghe, Stef De Lombaerde, Alan Miranda, Jordy Akkermans, Celia Dominguez, Vinod K. Khetarpal, Jonathan Bard, Longbin Liu, Steven G. Staelens, Daniele Bertoglio

This study evaluates [11C]CHDI-009R as a PET radioligand for quantifying mutant huntingtin aggregates in a mouse model of HD, showing high stability, reliability, and genotype differentiation.

Journal of Molecular Medicine · Dec 18, 2025Peer-reviewedNeuroscience

Preclinical evaluation of the novel CHDI-650 PET ligand for non-invasive quantification of mutant huntingtin aggregates in Huntington's disease

Franziska Zajicek, Jeroen A.J. Verhaeghe, Stef De Lombaerde, Annemie Van Eetveldt, Alan Miranda, Ignacio Muñoz-Sanjuán, Celia Dominguez, Vinod K. Khetarpal, Jonathan Bard, Longbin Liu, Steven G. Staelens, Daniele Bertoglio

This paper evaluates [18F]CHDI-650, a novel PET radiotracer, for imaging mutant huntingtin aggregates in HD mouse models, showing genotype discrimination at 3 and 9 months.

European Journal of Nuclear Medicine and Molecular Imaging · Aug 27, 2024Peer-reviewedNeuroscience

A novel imaging ligand as a biomarker for mutant huntingtin-lowering in Huntington's disease

Daniele Bertoglio, Jonathan Bard, Manuela Heßmann, Longbin Liu, Annette Gärtner, Stef De Lombaerde, Britta Huscher, Franziska Zajicek, Alan Miranda, Finn Peters, Frank Herrmann, Sabine Schaertl, Tamara Vasilkovska, Christopher J Brown, Peter D Johnson, , Ignacio Muñoz-Sanjuán

This paper develops a PET radioligand to visualize mutant huntingtin levels in the brain and assess therapeutic interventions in Huntington's disease.

bioRxiv · Jul 9, 2021 · PreprintNeuroscience