The paper identifies a fasting-induced microbiome-metabolite-chromatin axis that primes intestinal stem cells for regeneration after radiation injury.

Proceedings of the National Academy of Sciences · Jun 23, 2026Peer-reviewedCell Biology

Reprogramming of Cellular Plasticity via ETS and MYC Core-regulatory Circuits During Response to MAPK Inhibition in BRAF-mutant Colorectal Cancer

Hey Min Lee, Zhao Zheng, Alexey V. Sorokin, Chi Wut Wong, Stefania Napolitano, Saikat Chowdhury, Preeti Kanikarla Marie, Anand Kamal Singh, Veena Kochat, Christopher Aaron Bristow, Sanjana Srinivasan, Michael D. Peoples, Emre Arslan, Jumanah Yousef Alshenaifi, Oscar Eduardo. Villarreal, , Scott Kopetz

This study shows BET + MAPK inhibitors improve efficacy against BRAFV600E CRC by inducing epigenetic reprogramming and cellular plasticity through enhancer dynamics disruption.

Clinical Cancer Research · May 8, 2026Peer-reviewedCancer Biology

Spatially Anchored Regulatory State Inference in Melanoma

Jagan Mohan Reddy Dwarampudi, Veena Kochat, Suresh Satpati, Md Ishtyaq Mahmud, Humaira Anzum, Khalida Wani, Alexander Lazar, Ajay Kumar Saw, Jared C. Malke, Hien V Nguyen, Kunal Rai, Tania Banerjee

The paper develops a framework to integrate spatial transcriptomics with single-cell multiome data to infer spatially resolved regulatory programs in melanoma.

bioRxiv · Apr 8, 2026 · PreprintBioinformatics