Author

Jack C. Crowley

Cornell UniversityORCID 0000-0003-4220-8152Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Biophysics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Assay:imaging· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:dimensionality reduction· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:metabolism & bioenergetics· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

Claudia FischbachiD· 2 shared Ling LuiD· 2 shared Warren R. ZipfeliD· 2 shared Abdullah OzeriD· 1 shared Adrian A. ShimpiiD· 1 shared Alexander Yu. NikitiniD· 1 shared Amalie GaoiD· 1 shared Brittany E. SchutrumiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBioengineering

Claudia FischbachORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

BioengineeringAPL BioengineeringPeer-reviewedJul 1, 2026

Shape Factor Analysis as a Quantitative Framework for Assessing Spheroid and Organoid Morphology and Invasiveness

Brittany E. Schutrum, Jenny Deng, Ju Hee Kim…·Claudia Fischbach

This paper develops a shape factor analysis method to quantify spheroid and organoid morphology, showing it provides more reliable morphology assessments than standard shape descriptors.

DOI 10.1063/5.0333152

imagingstatistical model

𝕏 PostBluesky

BiophysicsbioRxivPreprintJul 28, 2025

Assessing cellular metabolic dynamics with NAD(P)H fluorescence polarization imaging

Ling Lu, Jack C. Crowley, Matthew L. Tan…·Warren R. Zipfel

This paper introduces FPRM, a fast, label-free imaging method to monitor cellular metabolism using NAD(P)H autofluorescence, and demonstrates its application in tracking metabolic changes under various perturbations.

4 citations

imagingmicroscopy & imaging analysis

𝕏 PostBluesky

GenomicsbioRxivPreprintDec 4, 2023

Nanoscale photobiotinylation, pulldown and sequencing of region-specific DNA from intact cells.

Thomas C. Roberts, Max H. Kushner, Jack C. Crowley…·Warren R. Zipfel

Femto-seq enables targeted DNA sequencing from specific nuclear regions in individual cells using nanoscale photobiotinylation and sequencing.

DOI 10.1101/2023.12.04.569951

DNA methylationwhole-genome sequencing

𝕏 PostBluesky