Warren R. Zipfel

This study shows that pro-inflammatory polarization of macrophages increases nuclear stiffness despite reduced lamin A/C levels, suggesting chromatin changes drive nuclear mechanics.

This paper introduces FPRM, a fast, label-free imaging method to monitor cellular metabolism using NAD(P)H autofluorescence, and demonstrates its application in tracking metabolic changes under various perturbations.

Femto-seq enables targeted DNA sequencing from specific nuclear regions in individual cells using nanoscale photobiotinylation and sequencing.