Claudia Fischbach

Shape Factor Analysis as a Quantitative Framework for Assessing Spheroid and Organoid Morphology and Invasiveness

This paper develops a shape factor analysis method to quantify spheroid and organoid morphology, showing it provides more reliable morphology assessments than standard shape descriptors.

Directional bone matrix mineralization in the CAM assay is governed by vascular integration and matrix remodeling

The paper investigates bone matrix mineralization in the CAM assay, finding that vascular integration and matrix remodeling govern mineral deposition.

Adipose-mimetic granular hydrogels uncover biophysical cues driving breast cancer invasion

This study uses adipose-mimetic hydrogels to show that soft mechanical cues from adipocytes enhance breast cancer cell invasion by altering ECM structure and cellular confinement.

Large adipocytes alter mode of lipid release and promote breast cancer malignancy

This study shows that large adipocytes release lipids via extracellular vesicles, promoting breast cancer cell migration and proliferation, and links this to human dyslipidemia and triglyceride levels.

Assessing cellular metabolic dynamics with NAD(P)H fluorescence polarization imaging

This paper introduces FPRM, a fast, label-free imaging method to monitor cellular metabolism using NAD(P)H autofluorescence, and demonstrates its application in tracking metabolic changes under various perturbations.

Bone mineral density affects tumor growth by shaping microenvironmental heterogeneity

This study shows that bone mineral density influences tumor growth by altering microenvironmental complexity in an organism-dependent manner.