Bryan B. Teefy

A multi-omic atlas in the African turquoise killifish reveals increased glucocorticoid signaling as a hallmark of brain aging

This study creates a multi-omic atlas of brain aging in African turquoise killifish, identifying glucocorticoid signaling activation as a key feature of aging and showing its inhibition can reverse aging phenotypes.

Transcriptional profiling of aging tissues from female and male African turquoise killifish

This paper provides a transcriptional dataset of aging tissues from African turquoise killifish, showing age has a greater impact than sex on gene expression and TE transcription.

Widespread sex-dimorphism across single-cell transcriptomes of adult African turquoise killifish tissues

The paper creates a single-cell gene expression atlas of adult African turquoise killifish tissues, revealing widespread sex-dimorphic gene expression, particularly in the liver, and identifies molecular markers for sex identity.

Dynamic regulation of gonadal transposon control across the lifespan of the naturally short-lived African turquoise killifish

The paper characterizes gonadal transcriptome changes across lifespan in African turquoise killifish, finding sex-specific declines in piRNA pathways and TE activity in ovaries with aging.

PIWI-piRNA pathway-mediated transposable element repression in Hydra somatic stem cells

This study shows the PIWI-piRNA pathway represses transposable elements in Hydra epithelial stem cells, preventing genomic damage and maintaining tissue integrity.