Author

Jacek Biernat

German Center for Neurodegenerative DiseasesORCID 0000-0003-4237-3975Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

Eckhard Mandelkow�iD· 2 shared Eva‐Maria MandelkowiD· 2 shared Senthilvelrajan KaniyappaniD· 2 shared Bettina WarscheidiD· 1 shared Christoph KlattiD· 1 shared Friedel DrepperiD· 1 shared Helmut E. MeyeriD· 1 shared Katharina Tepper· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersNeuroscience

Eckhard Mandelkow�ORCID

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2 papers

Recent·Most cited

Combinatorial native MS and LC-MS/MS approach reveals high intrinsic phosphorylation of human Tau but minimal levels of other key modifications

Friedel Drepper, Jacek Biernat, Senthilvelrajan Kaniyappan, Helmut E. Meyer, Eva‐Maria Mandelkow, Bettina Warscheid, Eckhard Mandelkow�

Journal of Biological Chemistry · Oct 26, 2020Peer-reviewedNeuroscience

FRET-based Tau seeding assay does not represent prion-like templated assembly of Tau fibers

Senthilvelrajan Kaniyappan, Katharina Tepper, Jacek Biernat, RamReddy Chandupatla, Sabrina Hübschmann, Stephan H. Irsen, Sandra Bicher, Christoph Klatt, Eva‐Maria Mandelkow, Eckhard Mandelkow�

This paper shows that FRET-based Tau seeding assays do not reflect prion-like templated assembly of Tau fibers, as GFP tags inhibit aggregation and alter fiber structure.

Molecular Neurodegeneration · Jul 16, 2020Peer-reviewedNeuroscience