Author

Sabrina Hübschmann

German Center for Neurodegenerative Diseases

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell-cell communication· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:differential expression· 1 Organism:mouse· 1 Assay:protein structure· 1

Frequent Co-Authors

Alvaro Dominguez‐Baquero· 2 shared Andrew G. NewmaniD· 2 shared Bilge AskiniD· 2 shared Cagla Kilic· 2 shared Elena De DomenicoiD· 2 shared Lisa DieziD· 2 shared Marc BeyeriD· 2 shared Pia Grundschöttel· 2 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersNeuroscience

Alvaro Dominguez‐Baquero

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Author profile →

3 papers

Recent·Most cited

IgLON5 autoimmune antibodies activate Tau via neuronal hyperactivity

Bilge Askin, Cagla Kilic, César Cordero Gómez, Sophie Lan-Linh Duong, Alvaro Dominguez‐Baquero, Alexander Goihl, Karsten Nalbach, Joana Petushi, Pia Grundschöttel, Jessica Wagner, Valentine Thomas, Janne Lamberty, Emily Withers, Hanna Huber, Sabrina Hübschmann, , Susanne Wegmann

This study shows that IgLON5 autoantibodies cause neuronal hyperactivity and Tau pathology by clustering cell surface proteins, linking them to neurodegeneration.

Science Advances · May 13, 2026Peer-reviewedNeuroscience

Tau modulates nuclear integrity, chromatin, and cholesterol synthesis genes via the nuclear envelope

Lisa Diez, Renata Ponce-Lina, Cagla Kilic, Rithika Sankar, Frieda Balduin, Cong Wang, Pia Grundschöttel, Koki Sakurai, Bilge Askin, Chiara Bordier, Tejaswini Karra, Katharina Tipp, Boglarka Krisztina Nagy-Herczeg, Maryam Mohamaddokht, Leandre M. Ravatt, , Susanne Wegmann

This study shows that increased somatodendritic Tau interacts with nuclear envelope proteins, causing nuclear damage and altering gene expression related to AD and tauopathies.

bioRxiv · Feb 14, 2026 · PreprintNeuroscience

FRET-based Tau seeding assay does not represent prion-like templated assembly of Tau fibers

Senthilvelrajan Kaniyappan, Katharina Tepper, Jacek Biernat, RamReddy Chandupatla, Sabrina Hübschmann, Stephan H. Irsen, Sandra Bicher, Christoph Klatt, Eva‐Maria Mandelkow, Eckhard Mandelkow�

This paper shows that FRET-based Tau seeding assays do not reflect prion-like templated assembly of Tau fibers, as GFP tags inhibit aggregation and alter fiber structure.

Molecular Neurodegeneration · Jul 16, 2020Peer-reviewedNeuroscience