Zhihua Liu

SQUALL integrates histology and spatial transcriptomics to enable virtual spatial gene expression profiling and clinical prediction across cancers and platforms.

This paper introduces Archimap, a spatial transcriptomic platform that profiles immune repertoires and microbiota in FFPE tissues, revealing antitumor immunity and therapeutic antibodies.

This paper identifies a low-affinity SARS-CoV-2 antibody, P5-1C8, that neutralizes Omicron JN.1 through IgG-mediated spike aggregation rather than direct binding.

The paper benchmarks five high-throughput subcellular spatial transcriptomics platforms using multi-omics data from cancer samples, evaluating performance across multiple metrics.

This study uses cryo-EM to show that the W328-6H2 antibody forms different structures with SARS and Omicron BA.1 spike proteins, revealing a supplementary neutralization mechanism beyond RBD-Fab binding.