Satoshi Yamazaki

This paper develops human iPSC-derived bone marrow organoids that support both hematopoiesis and thymus-like T cell differentiation, offering a platform for immune cell therapy and research.

This paper develops a system to predict hematopoietic stem cell diversity using quantitative phase imaging and machine learning, capturing temporal kinetics rather than single snapshots.

This study reveals bidirectional fate transitions between myeloid-biased and lineage-balanced hematopoietic stem cells using clonal phylogenetic tracing.

The paper characterizes Tet2-mutant HSCs using multi-omic data and identifies ECM molecules as regulators of self-renewal in pre-leukemic HSCs.

This study shows reducing oxidative stress enhances ex vivo growth of human haematopoietic stem and progenitor cells in polymer-based cultures and enables efficient gene editing.