Stress-primed secretory autophagy drives extracellular BDNF maturation
Silvia Martinelli, Elmira A. Anderzhanova, Svenja Wiechmann…·Nils C. Gassen
This study shows that stress enhances secretory autophagy via FKBP51, leading to increased MMP9 secretion and proBDNF cleavage to mature BDNF, linking stress adaptation to psychiatric disorders.