Robert Whelan

An open-access neuroimaging-compatible virtual town task for assessing human spatial navigation

The paper introduces an open-access virtual navigation task compatible with neuroimaging, demonstrating its use with EEG and behavioral tracking in human participants.

Early life stress alters lifespan trajectories of amygdala development: a cross-species model of amygdala burnout

The paper proposes the amygdala burnout hypothesis, showing early-life stress leads to initial amygdala volume increases in adolescence followed by reductions in older age across rodents and humans.

Reproducible Human Reward Imaging Phenotypes Exhibit Differential Sensitivity to Dopamine D2 Receptor Antagonism

The paper identifies two reproducible reward imaging phenotypes linked to dopamine D2 receptor function and shows differential responses to antipsychotic drugs.

MRI-free OPM-MEG recovers medial temporal lobe theta during scene imagination

This study shows that OPM-MEG can detect theta oscillation attenuation in the medial temporal lobe during scene imagination without requiring individual MRI scans.

Sex-specific associations of childhood adversity with frontostriatal network organization and anhedonia in young adulthood

The paper examines how childhood adversity dimensions relate to frontostriatal network connectivity and anhedonia in young adults, finding sex-specific associations.

Protracted Maturation of Proactive and Reactive Systems Predicts Cognitive Stability and Psychopathology : A longitudinal multi-cohort study

The paper uses longitudinal fMRI data to show that proactive and reactive control networks stabilize after mid-adolescence, predicting cognitive stability and psychopathology.

Adversity and adolescent brain development: differential associations with grey and white matter across two longitudinal cohorts

This study examines how different types of adversity affect grey and white matter development in adolescents across two cohorts, finding distinct associations between adversity types and brain structure metrics.

Trajectories of brain organisation transition from predicting externalising to internalising symptoms across adolescence

The paper uses longitudinal neuroimaging and behavioural data to show how brain-behaviour relationships shift from externalising to internalising symptoms across adolescence, identifying age 14 as a critical transition point.

Bullying Victimization and Brain Development: A Longitudinal Structural Magnetic Resonance Imaging Study from Adolescence to Early Adulthood

This study links bullying victimization to structural brain changes in adolescents and young adults, showing sex-specific effects on brain regions involved in emotion and motor function.

Digital Twin Brain simulation and manipulation of a functional brain network underlying mental illness

The paper develops a digital twin brain model that simulates and manipulates functional brain networks to predict mental illness symptoms and responses to interventions.

Uncovering Multi-Omics Profiles of Population Heterogeneity: A Cluster-Based Bayesian Approach

MOCHA identifies latent population subgroups with distinct genetic effects from multi-omics data, revealing two neurodevelopmental clusters linked to adolescent inhibitory control.

Limbic System White Matter in Children and Adolescents with ADHD: A Longitudinal Diffusion MRI Analysis

This study uses diffusion MRI to examine limbic system white matter development in children and adolescents with ADHD, finding reduced microstructural organization and connectivity linked to symptom severity.

Anatomical connectivity profile development constrains medial-lateral topography in the dorsal prefrontal cortex

This study identifies developmental differences between dorsomedial and dorsolateral prefrontal cortex using multimodal data and transcriptomics, revealing a medial-lateral topographic division.

Mapping the coupling between tract reachability and cortical geometry of the human brain

This study maps the coupling between cortical geometry and white matter tract connectivity, showing how these aspects jointly shape brain function.

Chronic pain is linked to a resting-state neural archetype that optimizes learning from punishments

The paper identifies a neural archetype associated with chronic pain susceptibility by analyzing resting-state networks in population and clinical samples.

Brain Diffusion Transformer for Personalized Neuroscience and Psychiatry

The paper introduces Brain-DiT, a deep generative model for analyzing task-fMRI data, identifying cognitive regions and subgroups linked to psychiatric conditions like depression and alcohol abuse.

Genetic-Dependent Brain Signatures of Resilience: Interactions among Childhood Abuse, Genetic Risks and Brain Function

The paper identifies a genetic-dependent brain signature of resilience linked to childhood abuse and depression risk in girls, showing its predictive value for emotional disorders in adolescence and early adulthood.

Regional patterns of human cortex development correlate with underlying neurobiology

The paper links regional human cortex development and aging to molecular and cellular brain organization patterns using neuroimaging and gene expression data.

Variation in moment-to-moment brain state engagement changes across development and contributes to individual differences in executive function

This study examines how variability in brain state engagement changes with age and its relationship to executive function in youth.

Adolescent maturation of cortical excitation-inhibition balance based on individualized biophysical network modeling

This study develops an individualized in vivo marker of excitation-inhibition balance in adolescents using biophysical network models and finds increased inhibition in association cortices during development.

A robust brain network for sustained attention from adolescence to adulthood that predicts later substance use

This study shows that a brain network for sustained attention at age 14 predicts increased cannabis and cigarette use by age 23 in a longitudinal cohort.

Adolescent to young adult longitudinal development of subcortical volumes in two European sites with four waves

The paper examines sex differences in subcortical brain volume trajectories across adolescence using longitudinal data from two European sites.

Connectome-based predictive modeling of cognitive reserve using task-based functional connectivity

The paper develops and validates a measure of cognitive reserve using task-based fMRI data and applies it to resting-state data, finding theoretical validity in some contexts but not others.

Federated analysis in COINSTAC reveals functional network connectivity and spectral links to smoking and alcohol consumption in nearly 2,000 adolescent brains

This study uses federated analysis in COINSTAC to examine functional network connectivity in adolescent brains linked to smoking and alcohol consumption, finding hypoconnectivity and reduced synchronization.

Investigating the contributions of circadian pathway and insomnia risk genes to autism and sleep disturbances

The paper investigates how copy number variants in circadian pathway and insomnia risk genes contribute to ASD risk and sleep disturbances in children with ASD.

Self-regulation of the brain's right frontal Beta rhythm using a brain-computer interface

This study shows participants could self-regulate their right frontal Beta rhythm using EEG neurofeedback, but no offline behavioral changes were observed.

The bidirectional causal effects of brain morphology across the life course and risk of Alzheimers disease: A cross-cohort comparison and Mendelian randomization meta-analysis

This study uses Mendelian randomization to examine bidirectional causal effects between brain morphology and Alzheimer's disease risk across different life stages.

Genetic variation in CSMD1 affects amygdala connectivity and prosocial behavior

This study identifies a genetic variant in CSMD1 associated with amygdala connectivity and prosocial behavior through a GWAS of brain networks in adolescents.

Cognitive and brain development is independently influenced by socioeconomic status and polygenic scores for educational attainment.

This study examines the independent effects of socioeconomic status and genetic factors on brain development and cognition in adolescents, finding distinct associations with cortical surface area and working memory.

Neurobehavioural characterisation and stratification of reinforcement-related behaviour

The paper characterises and stratifies reinforcement-related behaviours by analysing neural activation patterns in adolescents using a statistical framework.