Frederik Dethloff

This study shows that autophagy regulator ATG5 protects cerebellar Purkinje cells by maintaining glycolytic activity, preventing neurodegeneration through regulation of glucose transporter 2.

This study shows that butyrate is metabolized into the TCA cycle in fly heads and increases oxygen consumption without affecting proteome or acetylome.

This study identifies a unique glycogen metabolism in naked mole-rat hearts during ischaemia, involving liver-like mechanisms and amylase activation for enhanced glycolytic flux and ATP maintenance.

This study identifies FKBP51 as a molecular switch linking autophagy to metabolism in the mediobasal hypothalamus, showing its role in obesity regulation.

This study shows that stress enhances secretory autophagy via FKBP51, leading to increased MMP9 secretion and proBDNF cleavage to mature BDNF, linking stress adaptation to psychiatric disorders.