Author

Stephen A. McMahon

University of St AndrewsORCID 0000-0003-4273-8364Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Approach:biophysical modeling· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Malcolm F. WhiteiD· 3 shared Haotian ChiiD· 2 shared Shirley GrahamiD· 2 shared Silvia Snyowsky· 1 shared T.M. GlosteriD· 1 shared Ville HoikkalaiD· 1 shared Yu Sun· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

7 top collaborators · 13 mutual co-author links

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3 shared papersBiochemistry

Malcolm F. WhiteORCID

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3 papers

Recent·Most cited

MicrobiologybioRxivPreprintSep 18, 2026

A self-limiting dimeric TIR effector specialised for type III CRISPR-mediated immunity

Yu Sun, Stephen A. McMahon, Silvia Snyowsky, Malcolm F. White

The paper describes a dimeric TIR effector, TSR1, that binds cA3 and degrades it to auto-limit its activity in type III CRISPR-mediated antiviral immunity.

DOI 10.64898/2026.09.16.751991

experimental assayhost-pathogen & immune response

𝕏 PostBluesky

BiochemistryBiochemical JournalPeer-reviewedMar 30, 2026

The CRISPR ring nuclease Csx15 oligomerises on cyclic nucleotide binding to regulate antiviral defence

Haotian Chi, Stephen A. McMahon, Shirley Graham, Malcolm F. White

This study investigates the structural and biochemical properties of Csx15, a ring nuclease that binds cyclic nucleotides and regulates antiviral defense by modulating cOA levels.

1 citation

experimental assaybiophysical modeling

𝕏 PostBluesky

BiochemistryNature CommunicationsPeer-reviewedDec 15, 2025

Structure and mechanism of the broad spectrum CRISPR-associated ring nuclease Crn4

Haotian Chi, Ville Hoikkala, Stephen A. McMahon…·Malcolm F. White

This study describes the structure and mechanism of Crn4, a ring nuclease that degrades cyclic oligoadenylates and modulates type III CRISPR immunity.

3 citations

experimental assay

𝕏 PostBluesky