The paper develops a DNA methylation-based epigenetic clock to predict mortality and associate with clinical, immunological, and lifestyle factors related to intrinsic capacity.

Nature Aging · Jun 4, 2025Peer-reviewedGenomics

Pathogenicity of Commensal Gut Biofilm In Prefrail Aging

Guillaume Le Cosquer, Melissa Pannier, Elodie Servanne-Meunier, Julie Thevenin, Elise Pyhourquet, Sophie Guyonnet, Bruno J. Vellas, Yohan Santin, Bruno Pierre Guiard, Angelo Parini, Louis Buscail, Barbara Bournet, Damien Guillemet, Céline Deraison, Nathalie Vergnolle, , for the IHU HealthAge INSPIRE/Open Science study group

The paper investigates prefrail gut microbiota biofilm changes and their inflammatory effects, showing potential for microbiota-targeted interventions in aging.

npj Biofilms and Microbiomes · May 22, 2025Peer-reviewedMicrobiology

The genetic architecture of human brainstem structures and their involvement in common brain disorders

Torbjørn Elvsåshagen, Shahram Bahrami, Dennis van der Meer, Ingrid Agartz, Dag Alnæs, Deanna M. Barch, Ramona Baur‐Streubel, Alessandro Bertolino, Mona Kristiansen Beyer, Giuseppe Blasi, Stefan Borgwardt, Birgitte Boye, Jan K. Buitelaar, Erlend Bøen, Elisabeth Gulowsen Celius, , Tobias Kaufmann

The paper identifies genetic loci associated with brainstem volumes and finds genetic overlaps with psychiatric and neurological disorders.

Nature Communications · Aug 11, 2020Peer-reviewedNeuroscience

Genetics of brain age suggest an overlap with common brain disorders

Tobias Kaufmann, Dennis van der Meer, Nhat Trung Doan, Emanuel Schwarz, Martina Jonette Lund, Ingrid Agartz, Dag Alnæs, Deanna M. Barch, Ramona Baur‐Streubel, Alessandro Bertolino, Francesco Bettella, Mona Kristiansen Beyer, Erlend Bøen, Stefan Borgwardt, Christine Lycke Brandt, , Neurocognition and Genetics Study for the Pediatric Imaging

The paper estimates brain age gaps using MRI and machine learning in individuals with and without brain disorders, finding heritability and genetic overlap with common disorders.

Nature Neuroscience · Sep 24, 2019Peer-reviewedNeuroscience