Simon D. Weaver

This study shows that Mycobacterium marinum switches ESX-1 substrates in response to acidic pH, affecting phagosome lysis and bacterial survival.

This study shows that tyloxapol inhibits ESX-1 secretion in Mycobacterium marinum at low concentrations, affecting its lytic activity and potentially explaining its anti-tuberculosis effects.

This study identifies N-acetyltransferases in M. marinum that link iron uptake, aminoglycoside resistance, and virulence lipid production, revealing their multifunctional roles in pathogenesis.

The paper introduces OnePotNTA, a one-pot method for quantifying N-terminal acetylation in mycobacteria, achieving high coverage and reducing sample preparation time.

This study shows that loss of PDIM and PGL lipids in M. marinum reduces specific ESX-1 substrate secretion, impacting pathogenesis.