Author
University of Notre DameORCID 0000-0002-7827-8278Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Owen A. Collars, Richard L Hernandez, Simon D. Weaver…·Patricia A. DiGiuseppe Champion
This study shows that Mycobacterium marinum switches ESX-1 substrates in response to acidic pH, affecting phagosome lysis and bacterial survival.
Bradley S. Jones, Daniel D. Hu, Kathleen R. Nicholson…·Patricia A. DiGiuseppe Champion
This study shows that loss of PDIM and PGL lipids in M. marinum reduces specific ESX-1 substrate secretion, impacting pathogenesis.
Kathleen R. Nicholson, Rachel M. Cronin, Rebecca J. Prest…·Patricia A. DiGiuseppe Champion
This study identifies EspN as a critical transcription factor regulating the ESX-1 system in M. marinum, which is essential for macrophage infection and disease burden, but its activity is masked by EspM under laboratory conditions.