Patricia A. DiGiuseppe Champion

pH-responsive substrate switching in mycobacterial Type VII ESX secretion.

This study shows that Mycobacterium marinum switches ESX-1 substrates in response to acidic pH, affecting phagosome lysis and bacterial survival.

Tyloxapol inhibits ESX-1 secretion in Mycobacterium marinum

This study shows that tyloxapol inhibits ESX-1 secretion in Mycobacterium marinum at low concentrations, affecting its lytic activity and potentially explaining its anti-tuberculosis effects.

N-acetyl-transferases required for iron uptake and aminoglycoside resistance promote virulence lipid production in M. marinum

This study identifies N-acetyltransferases in M. marinum that link iron uptake, aminoglycoside resistance, and virulence lipid production, revealing their multifunctional roles in pathogenesis.

One-Pot Quantitation of Mycobacterial N-terminal Protein Acetylation Peptidoforms and Proteome

The paper introduces OnePotNTA, a one-pot method for quantifying N-terminal acetylation in mycobacteria, achieving high coverage and reducing sample preparation time.

The regulatory functions of ESX-1 substrates, EspE and EspF, are separable from secretion.

This study investigates the relationship between EspE and EspF secretion and their regulatory functions in mycobacteria, finding that their secretion is separable from their gene regulatory roles.