Stefano Beretta

A genetic anemia disentangles the dual effect of chronically reduced thrombopoietin on hematopoietic stem cells and bone marrow niche

This study uses a genetic anemia model to show that reduced thrombopoietin affects hematopoietic stem cells and the bone marrow niche through direct and indirect mechanisms.

Human iPSC-derived neural stem cells display a radial glia-like signature in vitro and favorable long-term safety in transplanted mice

This study characterizes the transcriptional and epigenetic profiles of hiPSC-NSCs and evaluates their safety in vivo, showing they resemble fetal NSCs and are safe for transplantation.

ASGAL: Aligning RNA-Seq Data to a Splicing Graph to Detect Novel Alternative Splicing Events

ASGAL aligns RNA-Seq data to a splicing graph to detect novel alternative splicing events, outperforming methods that align to a reference genome.

HapCHAT: Adaptive haplotype assembly for efficiently leveraging high coverage in long reads

HapCHAT improves haplotype assembly by adapting error thresholds for higher coverage long reads, enhancing accuracy and reducing computational resources.

Combining Bayesian Approaches and Evolutionary Techniques for the Inference of Breast Cancer Networks

This study compares Bayesian heuristics for inferring breast cancer gene networks from experimental data.