A genetic anemia disentangles the dual effect of chronically reduced thrombopoietin on hematopoietic stem cells and bone marrow niche
Annamaria Aprile, Alessandro Malara, Mariangela Storto, Alessandro Gulino, Valeria Cancila, Gaia Morello, Silvia Sighinolfi, Laura Raggi, Stefano Beretta, Ivan Merelli, Sarah Marktel, Maurilio Ponzoni, Claudio Tripodo, Alessandra Balduini, Giuliana Ferrari
This study uses a genetic anemia model to show that reduced thrombopoietin affects hematopoietic stem cells and the bone marrow niche through direct and indirect mechanisms.
bioRxiv · Oct 9, 2026 · PreprintCell Biology