Barbara Franke

This study performs a cross-disorder GWAS meta-analysis of ADHD, ASD, OCD, and TS, identifying 297 genome-wide significant variants and 21 genes associated with shared genetic risk.

This study investigates MAOA dysfunction in Brunner Syndrome using iPSC-derived dopaminergic neurons, finding increased NMDA receptor expression and network activity.

The paper examines how reactive and proactive aggression subtypes relate to distinct resting state functional connectivity patterns in children and adolescents with disruptive behavior.

The paper examines functional connectivity differences in children and adolescents with disruptive behavior, finding distinct patterns for reactive and proactive aggression and callous-unemotional traits, emphasizing the role of comorbid symptoms.

The paper identifies genetic correlations between ADHD and brain volumes, finding negative associations with intracranial volume and specific brain regions.

Cross-disorder meta-analysis of eight psychiatric GWAS (232,964 cases, 494,162 controls) reports 109 loci shared by two or more disorders and three groups of correlated disorders.

Genome-wide association meta-analysis of 20,183 ADHD cases and 35,191 controls finds 12 significant loci; signal concentrates in conserved regions, constrained genes, and CNS regulatory elements.

This study identifies 15 genome-wide significant loci associated with hippocampal subfield volumes in 21,297 individuals, revealing distinct genetic determinants for different subfields.

The paper analyzes cerebral cortical asymmetry in 17,141 healthy individuals, finding widespread hemispheric and regional asymmetries, associations with sex, age, brain size, and heritability.

This study investigates genetic mechanisms underlying sex bias in ADHD prevalence using genome-wide data and finds no mean polygenic burden difference across sexes but increased risk in female siblings and comorbid conditions.

The paper evaluates 15 candidate SNPs associated with psychiatric disorders using 6,165 diffusion MRI scans, finding no significant associations after correction for multiple testing.

This paper uses Gaussian Process Regression to explain missing heritability in yeast and rat phenotypes, finding that non-additive interactions account for most of the missing heritability.