Emma Sprooten

The multivariate genetic architecture of psychiatric and insulin resistance multimorbidity

This paper investigates the shared genetic architecture of psychiatric and insulin resistance conditions using multivariate GWAS and identifies potential biological mechanisms and drug candidates.

Genetic liability to major psychiatric disorders contributes to multi-faceted quality of life outcomes in children and adults

This study links genetic liability to psychiatric disorders with quality of life outcomes in children and adults, finding ADHD and MDD PGSs significantly associated with lower quality of life factors.

Independent Polygenic Component Scores Link Multivariate Brain Imaging Genetics to Diverse Phenotypes

This paper introduces polygenic component scores derived from genomICA components to link brain imaging genetics to diverse phenotypes, showing they predict physical and cognitive traits but not mental health outcomes.

The Genetic Architecture of Brain Structure and Function: A Data-Driven Interpretation Using genomICA

The paper applies genomICA to GWAS data from brain MRI phenotypes to identify genetic components associated with neurobiological processes and behaviors.

Principal and Independent Genomic Components of Brain Structure and Function

This paper introduces genomic principal and independent component analysis to decompose GWAS statistics of brain traits, showing improved reproducibility and interpretability of genetic effects.

Multi-polygenic scores in psychiatry: from disorder-specific to transdiagnostic perspectives

This study examines genetic liability for psychiatric disorders using disorder-specific and transdiagnostic frameworks, finding that depression PRS is associated with multiple disorders and uncovering four functional domains aligning with RDoC.

Dorsal to ventral imbalance in the superior longitudinal fasciculus mediates methylphenidate's effect on beta oscillations in ADHD

Shared genetic influences on resting-state functional networks of the brain

This study uses a multivariate method to identify shared genetic factors influencing resting-state brain networks and finds nine replicated SNPs associated with their joint architecture.

Longitudinal changes of ADHD symptoms in association with white matter microstructure: a tract-specific fixel-based analysis

The paper examines longitudinal ADHD symptom changes linked to white matter microstructure using fixel-based analysis, finding associations between symptom improvement and specific tract metrics.

Missing genetic links between general factors of brain resting-state functional magnetic resonance imaging, cognition and psychopathology

The paper investigates genetic overlap between psychopathology, cognition, and brain function using genetic correlation analyses of summary statistics from genome-wide association studies.

Task-generic and task-specific connectivity modulations in the ADHD brain: An integrated analysis across multiple tasks

This study identifies task-generic and task-specific connectivity modulations in ADHD brains across multiple tasks, finding reduced task-generic and increased task-specific connectivity in ADHD compared to controls and unaffected siblings.

Independent Genomic Sources of Brain Structure and Function

This paper introduces a method to identify latent genomic components influencing brain structure and function using GWAS summary statistics and MRI data, finding these components are enriched for molecular pathways and cell-specific gene expression.

Associations between ADHD symptom remission and white matter microstructure: a longitudinal analysis

This study examines how white matter microstructure changes longitudinally in relation to ADHD symptom remission in adolescents and young adults.

White matter microstructure in attention-deficit/hyperactivity disorder: a systematic tractography study in 654 individuals

The paper investigates white matter microstructure in ADHD using tractography, finding no significant FA associations with diagnosis but links lower FA in the right cingulum angular bundle to hyperactivity/impulsivity symptoms.

Sparse parallel independent component analysis and its application to identify linked genomic and gray matter alterations underlying working memory impairment in attention-deficit/hyperactivity disorder

This paper introduces spICA to link genomic and brain imaging data, identifying a SNP and GMV association in ADHD linked to working memory deficits.

A Non-Synonymous SHARPIN Variant is Associated with Limbic Degeneration and Family History of Alzheimer’s Disease

The paper identifies a SHARPIN variant associated with limbic system atrophy and family history of Alzheimer’s disease using MRI and genome-wide data.

Age-dependent genetic variants associated with longitudinal changes in brain structure across the lifespan

This study identifies genetic variants linked to longitudinal brain structure changes across the lifespan using MRI data from 15,640 individuals.

Shared genetic background between children and adults with attention deficit/hyperactivity disorder

This study identifies nine new genetic loci associated with ADHD and shows shared genetic architecture between childhood and adult ADHD.

Reduced fronto-striatal volume in ADHD in two cohorts across the lifespan

The paper uses independent component analysis to identify reduced fronto-striatal volume in ADHD across two cohorts, showing consistent results across age and demographic differences.

Discovering the shared biology of cognitive traits determined by genetic overlap

The paper investigates genetic and brain activation overlaps among cognitive traits, finding shared biological features between fluid intelligence and executive functioning.

Do Candidate Genes Affect the Brain’s White Matter Microstructure? Large-Scale Evaluation of 6,165 Diffusion MRI Scans

The paper evaluates 15 candidate SNPs associated with psychiatric disorders using 6,165 diffusion MRI scans, finding no significant associations after correction for multiple testing.