Author

Iara M. Backes

Dartmouth CollegeORCID 0000-0003-4389-6356Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Callaghan R. GarlandiD· 2 shared David A. LeibiD· 2 shared Lesle M JimeneziD· 2 shared Margaret E. AckermaniD· 2 shared Matthew D. SleiniD· 2 shared Alejandro Benjamin BalazsiD· 1 shared Anton M. SholukhiD· 1 shared Christine JohnstoniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersImmunology

Callaghan R. GarlandORCID

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2 papers

Recent·Most cited

ImmunologyJournal of VirologyPeer-reviewedMar 9, 2026

Antibodies targeting HSV glycoprotein B require effector functions to protect neonatal mice

Matthew D. Slein, Lesle M Jimenez, Iara M. Backes…·Margaret E. Ackerman

This study shows that gB-targeting antibodies protect neonatal mice from HSV infection, requiring both neutralization and Fc effector functions, with transgenerational protection achievable via AAV-mediated delivery.

1 citation

mouseexperimental assay

𝕏 PostBluesky

ImmunologyScience Translational MedicinePeer-reviewedNov 19, 2025

Improving antibody-mediated protection against HSV infection by eliminating interactions with the viral Fc receptor gE/gI

Matthew D. Slein, Iara M. Backes, Lesle M Jimenez…·Margaret E. Ackerman

The study shows engineered antibodies lacking Fc receptor binding improve HSV protection, suggesting vaccine strategies targeting IgG3 could enhance immunity.

6 citations

humanbulk RNA-seq

𝕏 PostBluesky