Author

Lesle M Jimenez

Dartmouth CollegeORCID 0000-0002-6072-4364Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

David A. LeibiD· 3 shared Margaret E. AckermaniD· 3 shared Matthew D. SleiniD· 3 shared Callaghan R. GarlandiD· 2 shared Iara M. BackesiD· 2 shared Alejandro Benjamin BalazsiD· 1 shared Anton M. SholukhiD· 1 shared Christine JohnstoniD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersImmunology

David A. LeibORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Interaction with complement factor C1q can contribute to and improve monoclonal antibody-mediated protection against lethal HSV-1 challenge

Lesle M Jimenez, Matthew D. Slein, David A. Leib, Margaret E. Ackerman

This study shows that modifying monoclonal antibodies to interact with complement factor C1q can enhance or reduce their ability to protect against lethal HSV-1 infection in neonatal mice.

bioRxiv · Oct 24, 2026 · PreprintImmunology

Antibodies targeting HSV glycoprotein B require effector functions to protect neonatal mice

Matthew D. Slein, Lesle M Jimenez, Iara M. Backes, Evelyn M. Turnbaugh, Callaghan R. Garland, Scott W. MacDonald, Alejandro Benjamin Balazs, David A. Leib, Margaret E. Ackerman

This study shows that gB-targeting antibodies protect neonatal mice from HSV infection, requiring both neutralization and Fc effector functions, with transgenerational protection achievable via AAV-mediated delivery.

Journal of Virology · Mar 9, 2026Peer-reviewedImmunology

Improving antibody-mediated protection against HSV infection by eliminating interactions with the viral Fc receptor gE/gI

Matthew D. Slein, Iara M. Backes, Lesle M Jimenez, Natasha S. Kelkar, Callaghan R. Garland, Urjeet S. Khanwalkar, Anton M. Sholukh, Christine Johnston, David A. Leib, Margaret E. Ackerman

The study shows engineered antibodies lacking Fc receptor binding improve HSV protection, suggesting vaccine strategies targeting IgG3 could enhance immunity.

Science Translational Medicine · Nov 19, 2025Peer-reviewedImmunology