Mattias Malaguti

The paper introduces KELPE, a cell line with dual genomic landing pads for efficient screening of synthetic gene circuits in pluripotent stem cells.

PUFFFIN labels cell neighbourhoods using a fluorescent protein fusion, enabling tracking of cell interactions and profiling non-cell-autonomous responses in mammalian cells.

SyNPL uses Synthetic Notch technology to monitor and manipulate cell-cell interactions in pluripotent stem cells and embryos, enabling synthetic patterning of cell fates.

This study shows that E2A drives neural differentiation in pluripotent mouse cells by activating neural lineage genes and repressing Nodal signalling.

This study shows that competence to epithelialise and differentiate in pluripotent cells is regulated by Tcf15, linking these processes through integrin alpha3 upregulation.

This study shows N-cadherin stabilizes neural identity by reducing anti-neural signals during differentiation.