Guillaume Blin

This study shows Notch signalling regulates human ENS progenitor dynamics, affecting differentiation and migration, and links its disruption to intestinal aganglionosis.

The paper introduces a toolkit to analyze cell identity patterning by comparing cells to their neighbors, revealing Notch-dependent heterogeneity in neuromesodermal progenitors.

This study identifies the signaling pathways and conditions required to generate notochord progenitors from human pluripotent stem cells in vitro.

SyNPL uses Synthetic Notch technology to monitor and manipulate cell-cell interactions in pluripotent stem cells and embryos, enabling synthetic patterning of cell fates.

This study shows that competence to epithelialise and differentiate in pluripotent cells is regulated by Tcf15, linking these processes through integrin alpha3 upregulation.

Nessys provides a method for accurate 3D nuclear segmentation in dense, heterogeneous tissues and tracks cell interactions during differentiation.

This study shows N-cadherin stabilizes neural identity by reducing anti-neural signals during differentiation.

This study shows that geometric cues can direct the self-patterning of Brachyury-positive cells in embryonic stem cell aggregates without relying on morphogen gradients.