Xin Tong

This study shows that MAFB is essential for maintaining adult human α-cell identity and function, linking its downregulation to impaired glucagon secretion and mitochondrial dysfunction in diabetes.

This study shows MYT1 and ST18 regulate human beta-cell survival and insulin secretion under normal and stress conditions, with their genes enriched for T2D-risk loci.

The paper identifies structural features in MAFA and MAFB transcription factors that influence their DNA-binding and Insulin enhancer activity through structural and functional analysis.

This paper identifies a MAFA S64F variant causing sex-dependent β cell dysfunction and diabetes by accelerating aging and senescence in males.

This study shows cigarette smoke exposure impairs β-cell function through oxidative stress and ceramide accumulation, with effects persisting after smoking cessation.