Maria F. Suárez Peredo Rodríguez

This study shows that chromosomal instability in TNBC increases EV secretion and promotes cell migration via EFEMP1, identifying EFEMP1 as a potential therapeutic target.

The paper shows that increased PRMT5-MEP50 complex activity helps aneuploid cancer cells survive by reducing protein aggregation and proteotoxicity.

The paper identifies ARGOS genes, which are amplified in cancer, have low expression relative to copy number, and are toxic when overexpressed, and validates several as pan-cancer targets.

The paper identifies CDC20 expression as a determinant of sensitivity to SAC inhibitors, showing that aneuploid cells with high CDC20 levels are more sensitive to these drugs.