Siqi Zheng

The paper shows that chromosomal instability (CIN) leads to distinct p21-expressing cell populations with different cell-cycle recovery and extracellular vesicle (EV) properties, resulting in increased migration.

This study shows that chromosomal instability in TNBC increases EV secretion and promotes cell migration via EFEMP1, identifying EFEMP1 as a potential therapeutic target.

The paper identifies CDC20 expression as a determinant of sensitivity to SAC inhibitors, showing that aneuploid cells with high CDC20 levels are more sensitive to these drugs.

The paper identifies HDAC4 as a synthetic lethal target in MELK-overexpressing cancers through a yeast screen and mammalian validation.