Siheng Xiang

The paper investigates how cohesin acetylation and ATPase activity regulate chromatin loop formation and cohesion in yeast, showing they operate through distinct mechanisms.

The paper identifies an interface between Scc2p and Smc1p that regulates cohesin ATPase activity and shows how acetylation of Smc3p inhibits this activity.

This study investigates cohesin architecture, oligomerization, and function in vivo using proximity-dependent labeling, revealing DNA binding by hinge and head domains and cell cycle-regulated oligomerization.