Douglas E. Koshland

This study shows cohesin suppresses unequal sister chromatid exchange by maintaining arm cohesion and limiting distal repeat interactions in yeast.

The paper investigates how cohesin acetylation and ATPase activity regulate chromatin loop formation and cohesion in yeast, showing they operate through distinct mechanisms.

The paper identifies an interface between Scc2p and Smc1p that regulates cohesin ATPase activity and shows how acetylation of Smc3p inhibits this activity.

The paper shows cohesin residency at CARs determines chromatin loop positioning in budding yeast through loop extrusion and CAR-bound cohesin stopping.

This study investigates cohesin architecture, oligomerization, and function in vivo using proximity-dependent labeling, revealing DNA binding by hinge and head domains and cell cycle-regulated oligomerization.

The paper shows that Cdc5p kinase, regulated by cohesin, controls condensin activity to properly fold the RDN into a thin loop during mitosis in budding yeast.

The paper shows that a cohesin subunit interface regulates DNA entrapment independently of a gate mechanism in yeast.

This study identifies Wpl1p as a regulator of cohesin functions in cohesion, condensation, and DNA repair through modulation of the Smc3p-Mcd1p interface.