Cancer BiologyACS Central SciencePeer-reviewed
Overcoming EGFR resistance by monovalent and bident inhibitors targeting Cys775
Zhengnian Li, Jie Jiang, Yaning Wang…·Tinghu Zhang
This paper develops covalent EGFR inhibitors targeting cysteine 775 and 797, showing improved efficacy and resistance delay in osimertinib-resistant models.
DOI 10.1021/acscentsci.6c01219