Author

Ilse K. Schaeffner

Harvard University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Michael J. EckiD· 2 shared Tyler S. BeyettiD· 2 shared Daniela Ortiz-Salazar· 1 shared Dhiraj Suda· 1 shared Dimitris GazgalisiD· 1 shared Felix H. GottliebiD· 1 shared Isidoro TavaresiD· 1 shared Jaimin K. RanaiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCancer Biology

Michael J. EckORCID

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2 papers

Recent·Most cited

Overcoming EGFR resistance by monovalent and bident inhibitors targeting Cys775

Zhengnian Li, Jie Jiang, Yaning Wang, Scott B. Ficarro, Stephen J. Collins, Tyler S. Beyett, Ilse K. Schaeffner, Isidoro Tavares, Felix H. Gottlieb, Dhiraj Suda, Prafulla C. Gokhale, Leah M. Black-Holmes, Dimitris Gazgalis, Michael J. Eck, Pasi Antero Janne, , Tinghu Zhang

This paper develops covalent EGFR inhibitors targeting cysteine 775 and 797, showing improved efficacy and resistance delay in osimertinib-resistant models.

ACS Central Science · Sep 29, 2026Peer-reviewedCancer Biology

Structure of the CABIT2 domain of THEMIS reveals a novel protein fold with an inserted SH3-like domain

Tyler S. Beyett, Zeynep Yurtsever, Ilse K. Schaeffner, Jaimin K. Rana, Lucy K. Robbie, Daniela Ortiz-Salazar, Michael J. Eck

The paper reports the crystal structure of the THEMIS CABIT2 domain, revealing a novel fold with an inserted SH3-like domain and insights into its interaction with GRB2.

bioRxiv · Oct 1, 2024 · PreprintBiochemistry