Patrick Callaerts

Neprilysin 1 in the Mushroom Body controls Feeding behavior by regulating SIFamide levels in Drosophila melanogaster

This study identifies Neprilysin 1 in the mushroom bodies as a regulator of SIFamide levels, which control feeding behavior in Drosophila melanogaster by shaping SIFamidergic signaling.

Synaptic connectome of a neurosecretory network in the Drosophila brain

The paper characterizes the synaptic connectome of neurosecretory cells in Drosophila, revealing their regulatory roles in physiology and behavior through input and output pathways.

Genome-wide analysis identifies Homothorax and Extradenticle as regulators of insulin in Drosophila Insulin-Producing cells

The paper uses GWAS on dilp expression data to identify genetic regulators in Drosophila IPCs, finding Homothorax and Extradenticle as key regulators of dilp expression.

The transposable element-rich genome of the cereal pest Sitophilus oryzae

The paper presents the genome of Sitophilus oryzae, revealing high transposable element content and host-symbiont metabolic interactions.

Ancestral regulatory mechanisms specify conserved midbrain circuitry in arthropods and vertebrates

The paper identifies conserved gene regulatory networks specifying midbrain circuitry in arthropods and vertebrates, showing functional parallels between Drosophila DTB and vertebrate MHB.

Growth control through regulation of insulin-signaling by nutrition-activated steroid hormone

This study identifies a nutrient-dependent mechanism by which 20-hydroxyecdysone regulates insulin signaling in Drosophila through the fat body and IPCs, revealing dual roles of 20E in growth regulation.