Frank Hirth

This paper identifies a fossilized brain in the trilobite Yunnanocephalus yunnanensis, revealing a bilaterally organized cerebrum with domains typical of euarthropod brain organization.

The paper describes the brain organization of Xandarella spectaculum, showing modifications from the ancestral cerebral ground pattern that may have contributed to its extinction.

This study shows that overexpressing α-synuclein variants alters presynaptic protein organisation without changing bouton structure, suggesting a disruption of presynaptic function through the MYCBP2-ELKS axis.

This paper describes the neural anatomy of Jianfengia multisegmentalis, a Cambrian stem euarthropod, and shows its similarities to modern Pancrustacea.

The paper identifies neuronal tissue structures in Mollisonia symmetrica that reveal a neuroanatomical organization distinct from merostomes, suggesting a marine origin for arachnids.

The paper shows that synaptotoxic forms of amyloid-beta and alpha-synuclein act through the same Wnt/PCP pathway to cause dendritic spine loss in neurodegenerative diseases.

The paper shows that yeast NDI1 restores metabolite levels, ER-mitochondria contacts, and rescues behavioral and lifespan defects in Drosophila with neuronal complex I deficiency.

This study shows that α-synuclein accumulation in presynaptic terminals causes synaptic dysfunction and progressive neurodegeneration in a Drosophila model, with similar findings in patient samples.

The paper identifies conserved gene regulatory networks specifying midbrain circuitry in arthropods and vertebrates, showing functional parallels between Drosophila DTB and vertebrate MHB.

This study investigates how dopamine D1 receptor signalling in Drosophila affects action sequences and turning behaviour using a novel behavioural paradigm.

The paper identifies a lineage-related reciprocal inhibition circuit in Drosophila that mediates sensory-motor action selection through competitive inhibition.