Author

Jéssika Cristina Bridi

King's College LondonORCID 0000-0002-7692-9866Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:Drosophila· 3 Research Focus:cell type annotation· 2 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Frank HirthiD· 4 shared Benjamin KottleriD· 3 shared Beate Hartmann· 1 shared Christopher J. H. ElliottiD· 1 shared Dag AarslandiD· 1 shared Deepak P. SrivastavaiD· 1 shared Diane P. HangeriD· 1 shared Erika BereczkiiD· 1 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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4 shared papersNeuroscience

Frank HirthORCID

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4 papers

Recent·Most cited

Overexpression of α-Synuclein Alters The Nanoscopic Organisation of Presynaptic Proteins

Iain A. Watson, Jéssika Cristina Bridi, Diane P. Hanger, Frank Hirth, Deepak P. Srivastava

This study shows that overexpressing α-synuclein variants alters presynaptic protein organisation without changing bouton structure, suggesting a disruption of presynaptic function through the MYCBP2-ELKS axis.

bioRxiv · Oct 10, 2025 · PreprintNeuroscience

Presynaptic accumulation of α-synuclein causes synaptopathy and progressive neurodegeneration

Jéssika Cristina Bridi, Erika Bereczki, Saffron K. Smith, Gonçalo M. Poças, Benjamin Kottler, Pedro Manuel Dias Neto Domingos, Christopher J. H. Elliott, Dag Aarsland, Frank Hirth

This study shows that α-synuclein accumulation in presynaptic terminals causes synaptic dysfunction and progressive neurodegeneration in a Drosophila model, with similar findings in patient samples.

Brain Communications · Mar 19, 2021Peer-reviewedNeuroscience

Ancestral regulatory mechanisms specify conserved midbrain circuitry in arthropods and vertebrates

Jéssika Cristina Bridi, Zoe N. Ludlow, Benjamin Kottler, Beate Hartmann, Lies Vanden Broeck, Jonah Dearlove, Markus Göker, Nicholas James Strausfeld, Patrick Callaerts, Frank Hirth

The paper identifies conserved gene regulatory networks specifying midbrain circuitry in arthropods and vertebrates, showing functional parallels between Drosophila DTB and vertebrate MHB.

Proceedings of the National Academy of Sciences · Aug 3, 2020Peer-reviewedNeuroscience

Dopamine D1 receptor signalling differentially regulates action sequences and turning behaviour in freely moving Drosophila

Benjamin Kottler, Richard Faville, Jéssika Cristina Bridi, Frank Hirth

This study investigates how dopamine D1 receptor signalling in Drosophila affects action sequences and turning behaviour using a novel behavioural paradigm.

bioRxiv · Aug 6, 2018 · PreprintNeuroscience