Akash Pal

The paper introduces BLADe, a platform that converts intracellular activity into photoreceptor activation using bioluminescent sensors and actuators, demonstrating its use in neurons for activity-dependent gene expression and neural dynamics control.

The paper shows how stochastic neuropeptide signals (NPY and MSH) compete to regulate cAMP levels in neurons, influencing satiation through state-dependent integration.

The paper introduces a method to control synaptically connected neurons using bioluminescent light, validated in cultured neurons and mice.

The paper shows that hyperexcitation of specific neocortical neurons during early development causes long-term behavioral and circuit deficits in adulthood.

This study uses bioluminescent-optogenetics to stimulate spinal cord neurons after injury, improving locomotor recovery in rats.