Jacque Pak Kan Ip

This study identifies CDKL5-mediated phosphorylation of nELAVL as critical for regulating RNA metabolism and condensate communication, essential for visual cortex maturation.

This study identifies circHomer1 as a circRNA critical for synaptic development and experience-dependent plasticity in mouse visual cortex through transcriptome analysis and knockdown experiments.

The paper introduces ENS2, a neural network system for spike inference from calcium imaging data, which outperforms existing methods in spike-rate and spike-event prediction with lower computational cost.

This paper introduces a non-toxic rabies virus system for long-term in vivo imaging of neuronal networks, showing minimal toxicity and normal visual response properties over 10 weeks.

The paper shows that local synaptic plasticity, mediated by Arc, coordinates potentiation and depression of adjacent spines to shape functional neuronal responses in vivo.