Chloe Delepine

Early differential impact of MeCP2 mutations on functional networks in Rett syndrome patient-derived human cerebral organoids

This study examines how different MeCP2 mutations affect neuronal activity and network function in Rett syndrome organoids, finding mutation-specific impairments in connectivity and gene expression.

The noncoding circular RNA circHomer1 regulates synaptic development and experience-dependent plasticity in mouse visual cortex

This study identifies circHomer1 as a circRNA critical for synaptic development and experience-dependent plasticity in mouse visual cortex through transcriptome analysis and knockdown experiments.

Label-free three-photon imaging of intact human cerebral organoids: tracking early events in brain development and deficits in Rett Syndrome

Astrocyte glutamate transport is modulated by motor learning and regulates neuronal correlations and movement encoding by motor cortex neurons