Allison J. Hollatz

The paper investigates the role of the Fkh1 FHA domain in promoting early S-phase DNA replication origins and inhibiting late origins by modulating chromatin structure and ORC-origin interactions.

This study identifies the FHA domain of Fkh1 as a factor that enhances ORC binding to a subset of DNA replication origins in budding yeast by interacting with specific DNA sequences.

This study uses a Drosophila model to show that a Meier-Gorlin Syndrome mutation in Orc4 causes tissue-specific DNA replication defects, particularly affecting female fertility.