Satoshi Okawa

This study shows that macrophage fatty acid synthesis promotes fibroblast expansion and fibrosis after myocardial infarction.

The paper shows that mitochondrial iron transport via MFRN1 is essential for erythroid cell cycle progression and terminal differentiation.

This study shows Etv5 is not needed for Schwann cell development but is essential for regulating their response to peripheral nerve injury.

The paper identifies NCOA7's role in lysosomal function and inflammatory sterol metabolism in PAH, showing its deficiency exacerbates disease through oxysterol/bile acid generation.

The paper identifies NEUROG2's role in regulating a human-specific gene regulatory program in neural progenitor cells through transcriptomic analysis of knock-in organoids.

This study shows IFI16, regulated by m6A modification, drives inflammatory endothelial changes in pulmonary arterial hypertension.

The paper shows glycolytic flux promotes rod photoreceptor differentiation by regulating Wnt signaling in murine retinal progenitor cells.

The paper identifies repurposable drugs for mitochondrial disease by using deep learning to screen for compounds that improve neuronal commitment and neurogenesis in Leigh syndrome organoids.

This study shows Pten and Dscam regulate amacrine cell spacing through endocytic trafficking of cell adhesion and signaling molecules, with altered extracellular vesicles and Wnt signaling in Pten mutants.

The paper identifies a proneural gene combinatorial code that diversifies neocortical neural progenitor cells through gene regulatory networks and cell fate decisions.

ChemPert provides a database of transcriptional responses in non-cancer cells to improve drug response predictions for non-cancer diseases.

The paper shows Neurog2 and Ascl1 genes regulate cortical progenitor differentiation and folding through Notch signaling in lissencephalic brains.

The paper uses single-cell RNA sequencing to analyze cardiac progenitor cells during normal and abnormal cardiogenesis, identifying transcriptional changes linked to congenital heart defects.

The paper identifies a conserved LPA signaling pathway that controls apical membrane size and maintains epithelial organization in neuroepithelial rosettes.