Author

Felix Steinruecke

Harvard UniversityORCID 0000-0003-4597-8232Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:ChIP-seq· 1 Organism:human· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Lucas FarnungiD· 3 shared Abhilash JayarajiD· 1 shared Bhasker DharavathiD· 1 shared Della SyauiD· 1 shared Ernst SchmidiD· 1 shared Haribabu ArthanariiD· 1 shared Hyunjee Lee· 1 shared Johannes C. WalteriD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersMolecular Biology

Lucas FarnungORCID

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3 papers

Recent·Most cited

ssDNA hand-off from RPA to Polθ drives microhomology-mediated end-joining

Martha Longley, Hyunjee Lee, Owen Eby, Bhasker Dharavath, Yufan Wu, Abhilash Jayaraj, Felix Steinruecke, Haribabu Arthanari, Ralph Scully, Lucas Farnung, Joseph J. Loparo, Johannes Walter

The paper reveals that RPA activates TMEJ by facilitating ssDNA hand-off to Polθ, which initiates microhomology search for DNA repair.

bioRxiv · Oct 28, 2026 · PreprintBiochemistry

Structure and function of IWS1 in transcription elongation

Della Syau, Felix Steinruecke, Sophie Roth, Ernst Schmid, Karen Adelman, Johannes C. Walter, Lucas Farnung

This study identifies IWS1 as a modular scaffold that organizes the transcription elongation complex through its disordered region, revealing its role in recruitment and stimulation of elongation.

Nucleic Acids Research · Apr 9, 2026Peer-reviewedMolecular Biology

Structural basis of human replisome progression into a nucleosome

Felix Steinruecke, Jonathan W. Markert, Lucas Farnung

This study presents cryo-EM structures of the human replisome interacting with a nucleosome, revealing DNA unwrapping and nucleosome disassembly mechanisms during replication.

bioRxiv · Apr 4, 2025 · PreprintMolecular Biology