Simon Raffel

This study uses Perturb-seq to identify gene regulatory programs in HSPCs that link genetic regulators to cell biological processes and stem cell phenotypes.

This study links multiscale biological interactions to clinical outcomes in AML by analyzing single-cell data and developing an analytical framework.

This paper introduces a computer vision platform that detects live mutant blood cells with specific mutations using morphology recognition, without requiring nucleic acid sequencing.

This paper introduces EPI-clone, a method using DNA methylation to trace clonal lineages in hematopoiesis without genetic engineering, showing clonal complexity declines with age in mice and expands in humans.

The paper identifies and profiles leukemic and pre-leukemic stem cells using single-cell transcriptomics combined with lineage tracing via somatic variants.