Stefan Wiemann

The paper identifies a fetal-like stem cell trajectory in colorectal cancer using multi-omics and organoid models, linked to poor prognosis and SRC/mTOR dependency.

This study shows PAK1 activation leads to different resistance mechanisms against Tamoxifen and aromatase inhibitors in luminal A breast cancer by affecting apoptosis and proliferation through distinct pathways.

This study identifies GLYATL1 as a mediator of endocrine resistance in luminal breast cancer by promoting metabolic and epigenetic changes that counteract estrogen deprivation.

The paper shows that inducing epithelial traits in breast cancer cells increases autophagy and DNA damage, potentially contributing to tumor dormancy and reactivation.

This study identifies molecular vulnerabilities in colorectal cancer by analyzing MSI and MSS tumors, revealing distinct signaling pathways and potential therapeutic targets.

The paper identifies DNA methylation markers associated with endocrine therapy resistance in ER+/HER2- breast cancer using TCGA data and cell line experiments.

The paper identifies 701 genes associated with human mitotic phases through transcriptomics analysis, including 205 putative cell cycle genes and 53 uncharacterised ones, with some showing novel centrosomal localization or proliferation inhibition.

This paper presents a pipeline for identifying and prioritizing causal variants in genetic disorders using exome or whole genome sequencing data, achieving success in over 35% of neurodevelopmental disorder cases.